Here’s a roundup of firms around North Carolina that recently submitted filings with Securities and Exchange Commission:

Altis Biosystems, Inc., a Chapel Hill-based biotech research tools company, has raised $934,592 in equity. Seven investors contributed to the round, with $1,258,003 remaining to be sold. The filing notes the funds will be used “for none  other than payments of salary in the ordinary course of business.” The firm is currently developing a stem cell co-culture cassette for advanced compound screening to make drug discovery faster and cheaper. The project is sponsored by the National Institutes of Health, Department of Health and Human Services.

Innovate Biopharmaceuticals, Inc.,  a Raleigh-based clinical stage biotechnology company focused on developing novel autoimmune and inflammation therapeutics, has raised $2.7 million in debt. One investor contributed to the round. The filing notes the funds will be used for “none other than payments of salary and other compensation in the ordinary course of business.” Innovate has a late-stage clinical pipeline of drugs addressing unmet needs in diseases such as celiac disease, inflammatory bowel disease and nonalcoholic steatohepatitis.

vTv Therapeutics Inc., a High Point-based clinical-stage biopharma company, has raised $2 million in equity and options. The company is vTv Therapeutics Inc. is focused on developing oral small molecule drug candidates. vTv has a pipeline of clinical drug candidates led by programs for the treatment of type 1 diabetes, Alzheimer’s disease, and inflammatory disorders. vTv’s development partners are pursuing additional indications in type 2 diabetes, COPD, and genetic mitochondrial diseases.

Avadim Health, Inc., a life science company based out of Asheville, has raised $64,000 in equity. The filings are listed here, here and here on the same day. Avadim was founded in 2007 with a mission to identify unmet needs through a portfolio of advanced, safe solutions. One of its main products is Theraworx. Theraworx Protect focuses on the reduction of hospital-acquired conditions. Theraworx Relief is foam or spray that serves to mitigate the development of muscle cramps.

Activegraf Inc., a Charlotte-based interactive analytics firm, has raised $900,000 in equity from one investor. The firm offers an analytics tool that connects existing Excel models and Powerpoint presentations.

Report: Early-stage startups likely to see funding crunch in 2020