In today’s Bulldog update of technology news: Pappas teams with Wake Forest Baptist for $15M fund; Chimerix gets early results on antiviral drug; Square 1 Bank now a Pacific Western division.

Durham-based venture capital firm Pappas Ventures is teaming with Wake Forest Baptist Medical Center in Winston-Salem on a $15 million fund intended to develop “ideas, discoveries and inventions” created by Wake Forest Medical Center into working technologies. The Triangle Business Journal reported the story.

It will specifically support those technologies d”clinically important” for licensing to startups and established companies.

For the full story at TBJ see: http://www.bizjournals.com/triangle/blog/techflash/2015/10/pappas-ventures-durham-nc-wfbmc-tech-fund.html

Chimerix gets early results on antiviral drug

Chimerix, Inc. (NASDAQ:CMRX), a biopharmaceutical company developing novel, oral antivirals in areas of high unmet medical need, disclosed preliminary data from liver transplant patients who received brincidofovir for adenovirus infection.

All patients with adenovirus viremia or localized infection (n=5) survived; seven of eight patients with disseminated adenovirus disease survived. Two patients experienced serious brincidofovir-related adverse events (diarrhea and increased stool volume, respectively), and no brincidofovir-associated liver adverse events were reported. In ten of eleven patients for whom viral load data were available, adenovirus levels in blood were either below quantifiable levels or were undetectable by the end of treatment.

“Adenovirus has been reported in up to 10% of pediatric liver transplant patients, but may be underdiagnosed,” said W. Garrett Nichols, M.D., M.S., Chief Medical Officer of Chimerix. “With no current FDA-approved treatment for adenovirus infection, there is a great unmet medical need for immunocompromised patients, including liver transplant recipients. These data support the continued study of brincidofovir for the prevention and treatment of double-stranded DNA virus infections, including adenovirus, in solid organ transplant recipients.”

Basically, that means the company will pursue further study of the drug.

Square 1 Bank now officially part of Pacific Western

Square 1 Bank is now Square 1 Bank, a division of Pacific Western Bank. Square 1 says the transition brings access to additional capital and increased capability, equipping its team with a broader range of products and services to provide the tools you needed to grow your business. And although it is now part of a larger bank, it says its mission – to be the best banking partner for entrepreneurs and their investors – remains the same, and is stronger than ever.

1 Bank’s industry expertise, products and services with PacWest’s track record, momentum and scale, we are well-positioned to strengthen our offeri