Inspire Pharmaceuticals, Inc. (Nasdaq: ISPH) has shuffled its leadership, naming a replacement for chairman of the board and a new member, while a promoting a senior vice president to president.

W. Leigh Thompson takes over as chairman, replacing Terrance G. McGuire of Polaris Venture Partners, whose term has expired. The board also elected of Kip Frey to the board and promoted Gregory J. Mossinghoff to president. Durham-based Inspire’s board remains at seven.

Mossinghoff, 41, has been promoted from senior vice president and chief business officer to the position of president. He will continue to report to Christy Shaffer, chief executive officer of Inspire, whose role in the company remains unchanged.

Inspire says Mossinghoff will continue to oversee corporate development, finance, strategic planning and operations, and serve as secretary and treasurer for the company. In addition, he will oversee the development of commercial operations for Inspire.

Mossinghoff has 14 years’ experience in the pharmaceutical industry, including positions of increasing responsibility at Roche Holding Ltd. and Glaxo Wellcome, plc. He received a B.A. degree in Economics from the University of Virginia and an M.B.A. in Financial Management & Analysis from George Mason University.

Thompson, the new chairman, retired from Eli Lilly and Co., where he served as chief scientific officer and as a member of the management committee. He has served on Inspire’s board since 1996.

New board member Frey is currently a professor of the Practice in Entrepreneurial Management & Law at Duke University with joint appointments from the Fuqua School of Business and Duke Law School. Prior to this, he was vice president and general manager of dynamic commerce applications for Siebel Systems, formerly OpenSite Technologies, an Intersouth portfolio company. Over the past five years, Frey has been the architect of three of RTP’s most notable entrepreneurial deals, together generating more than $1 billion of investor returns.

Inspire Pharmaceuticals: www.inspirepharm.com