Investors have placed almost $400 million in high-tech firms in the Carolinas and Georgia so far this year. Almost 50 deals have been made.

Here is Local Tech Wire’s exclusive list, ranking deals in order by size:

Company; Industry; Amount (Round)

1. Movaz Networks, Norcross, Ga.; Telecom; $60 million (3rd)

Investors: Oak Investment Partners (lead), Anschutz Investments, GATX Ventures, Menlo Ventures, Meritech Capital Partners, Silicon Valley BancVentures, Telus Ventures and Worldview Technology Partners

2. Inhibitex, Atlanta; Biotech; $45.4 million (4th)

Investors: Essex Woodlands Health Ventures (co-lead), New Enterprise Associates (co-lead), Alliance Technology Ventures, CDP Sofinov, Pacific Horizon Ventures and William Blair Capital Partners

3. Pathfire, Roswell, Ga.; Software; $27 million (5th)

Investors: AT&T Ventures, Bank of America Capital Investors, CNN News Group, Halpern Denny & Co., Institutional Venture Partners, Kinetic Ventures, Monarch Capital Partners, Noro-Moseley Partners, Quadrangle Group, Reuters Greenhouse Fund, Riggs Capital Partners and US Venture Partners

4. Wave 7 Optics, Alpharetta, Ga.; Telecom; $23 million (2nd)

Investors: ATV Capital (lead), Armada Ventures, Lucent Venture Partners, Mellon Ventures and Morganthaler Ventures

5. BioStratum, Durham; Biotech; $20 million (3rd)

Investors: BankInvest, Equity Resources Group, HealthCap and MP Bio

6. Servigistics, Atlanta; Software; $18 million (3rd)

Investors: Bain Capital Ventures (lead), Cordova Intellimedia Ventures, Encubate Technology Ventures, Robinson-Humphrey Netlanta Fund, SSM Ventures, Symphony Technology Group and UPS Strategic Enterprise Fund

7. Greenway Medical Technologies, Carrollton, Ga.; Software; $15 million (3rd)

Investors: Individuals

8. Norak Biosciences, Research Triangle Park; Biotech; $13 million (2nd)

Investors: Noro-Moseley Partners (lead), Alexandria Real Estate Equities, Aurora Funds, Intersouth Partners, Koch Ventures and Mitsui & Co. Venture Partners

9. N2 Broadband, Duluth, Ga.; IT services; $10 million (2nd)

Investors: Highland Capital Partners (lead) and AOL Time Warner Ventures

10. Peak 10, Charlotte; IT services; $9.2 million (3rd)

Investors: Frontier Capital and Seaport Capital

11. MediaSpan, Durham; Media; $8.5 million (1st)

Investors: Covestco-Seteura, Rustic Canyon Group, Southeast Interactive Technology Funds

11. Fast-Talk Communications, Atlanta; IT services; $8.5 million (2nd)

Investors: Boston Millennia Partners (lead), Atlanta Technology Angels, Cordova Ventures, HIG Ventures and SAIC Venture Capital

13. GenPhar, Mount Pleasant, S.C.; Biotech; $8 million (1st)

Investors: Individuals

14. NetOctave, Morrisville, N.C.; IT services; $7.8 million (2nd)

Investors: Intersouth Partners (lead), Intel Communications Fund, Kitty Hawk Capital, MCNC, North Carolina Enterprise Fund and Wakefield Group

15. iOnosphere, Greenville, S.C.; Telecom; $7 million (2nd)

Investors: Pharos Capital (lead) and Trelys Venture Partners

15. Zoom Culture, Chapel Hill; Media; $7 million (2nd)

Investors: Chrysalis Ventures (lead), Atlantis Group, Charlotte Angel Partners, Cordova Ventures, Intersouth Partners and Tri-State Investment Group.

17. Netifice Communications, Atlanta; Telecom; $6.5 million (3rd)

Investors: Boston Millennia Partners, Columbia Capital and HIG Ventures

18. Cropsolution, Morrisville, N.C.; Biotech; $6.4 million (1st)

Investors: Aurora Funds (lead), ATP Capital, Atlantis Group, Charlotte Angel Partners and Research Triangle Ventures

19. HAHT Commerce, Raleigh; Software; $6 million (2nd)

Investors: Canaan Partners

20. ChannelAdvisor, Morrisville, N.C.; Software; $5.7 million (2nd)

Investors: Genesis Venture Partners (lead), eBay, Southern Capitol Ventures, The Atlantis Group and Tri-State Investment Group

21. Lancope, Alpharetta, Ga.; Software; $5.55 million (1st)

Investors: GMG Capital Partners and HIG Capital

22. EG Technology, Atlanta; Telecom; $5.5 million (1st)

Investors: Noro-Moseley Partners (lead), Gray Ventures, HIG Ventures and Yamacraw Seed Capital

23. KnowledgeStorm, Alpharetta, Ga.; IT services; $5.25 million (2nd)

Investors: Sterling Venture Partners (lead), Apex Venture Partners, Imlay Investments, Live Oak Equity Partners and Total Technology Ventures

24. Datatrac, Atlanta; Software; $5 million (NA)

Investors: Megunticook Fund

24., Atlanta; Internet; $5 million (4th)

Investors: Healthsouth, UBS Warburg

24. SiteScape, Wilmington, N.C.; IT services; $5 million (2nd)

Investors: Echelon Ventures, SAIC Venture Capital

24. CipherOptics, Raleigh; IT services; $5 million (1st)

Investors: Kodiak Venture Partners

24. eCompanyStore, Atlanta; Internet; $5 million (NA)

Investors: ITC Holdings

29. AppGate, Durham; IT services; $4 million (3rd)

Investors: ABN Amro (co-lead), GE Equity (co-lead), Bure Equity, Industrifinans, Innovationskapital and Pythagoras

29., Atlanta; Internet; $4 million (NA)

Investors: Individuals

31. DarPharma, Chapel Hill; Biotech; $3.2 million (1st)

Investors: Stanley Foundation and individuals

32. Trinity Convergence, Raleigh; Telecom; $3.1 million (1st)

Investors: Core Capital Partners, Intersouth Partners, Mid-Atlantic Venture Funds

33. ConstructWare, Alpharetta, Ga.; Software; $3 million (3rd)

Investors: Cordova Ventures, Live Oak Equity Partners and Smith Harbor Ventures

34. LiveWire Logic, Morrisville, N.C.; IT services; $2.8 million (2nd)

Investors: Gray Ventures (lead), A.M. Pappas & Associates, The Atlantis Group, Charlotte Angel Partners, Research Triangle Ventures, Tri-State Investment Group, truePilot and individuals

35. nTouch Research, Raleigh; Pharmaceutical services; $2.6 million (3rd)

Investors: Canaan Partners (co-lead), Intersouth Partners (co-lead), Bioventures and Tri-State Investment Group

36., Atlanta; Internet; $2.5 million (1st)

Investors: Imlay Investments and individuals

37. Relativity Technologies, Cary; Software; $2 million (3rd)

Investors: Noro-Moseley Partners and Wakefield Group

38. Somatocor, Atlanta; Biotech; $1.7 million (seed)

Investors: Alliance Technology Ventures

39. epipeline, Atlanta; Internet; $1.5 million (3rd)

Investors: Crossbow Ventures

39. Gentris, Morrisville, N.C.; Biotech; $1.5 million (1st)

Investors: Exelixis, Research Triangle Ventures and individuals

39., Atlanta; Internet; $1.5 million (3rd)

Investors: Stephens

39. BioResource International, Raleigh; Biotech; $1.5 million (1st)

Investors: Chinese venture firm and individuals

43. Fortel DTV, Duluth, Ga.; IT services; $1 million (NA)

Investors: Individuals

43. ChemCodes, Durham; Biotech; $1 million (2nd)

Investors: Emerging Technology Partners

45. Xanthon, Research Triangle Park; Biotech; NA (4th)

Investors: Aurora Funds, Franklin Street Partners, Intersouth Partners and Noro-Moseley Partners

45. BuildLinks, Raleigh; Software; NA (2nd)

Investors: Knier and Associates

45. Waveguide Solutions, Charlotte; Semiconductors; NA (2nd)

Investors: Academy Venture Funds and Southeast Interactive Technology Funds

45. ZapMedia, Atlanta; Telecom; NA (2nd)

Investors: Five Paces Ventures

45. MindValve, Charlotte; Software; NA (Seed)

Investors: Academy Venture Funds