Investors have placed more than $300 million in high-tech firms in the Carolinas and Georgia so far this year. More than 40 deals have been made.

Here is Local Tech Wire’s exclusive list, ranking deals in order by size:

Company; Industry; Amount (Round)

1. Inhibitex, Atlanta; Biotech; $45.4 million (4th)

Investors: Essex Woodlands Health Ventures (co-lead), New Enterprise Associates (co-lead), Alliance Technology Ventures, CDP Sofinov, Pacific Horizon Ventures and William Blair Capital Partners

2. Pathfire, Roswell, Ga.; Software; $27 million (5th)

Investors: AT&T Ventures, Bank of America Capital Investors, CNN News Group, Halpern Denny & Co., Institutional Venture Partners, Kinetic Ventures, Monarch Capital Partners, Noro-Moseley Partners, Quadrangle Group, Reuters Greenhouse Fund, Riggs Capital Partners and US Venture Partners.

3. Wave 7 Optics, Alpharetta, Ga.;Telecom; $23 million (2nd)

Investors: ATV Capital (lead), Armada Ventures, Lucent Venture Partners, Mellon Ventures and Morganthaler Ventures

4. BioStratum, Durham; Biotech; $20 million (3rd)

Investors: BankInvest, Equity Resources Group, HealthCap, MPBio

5. Servigistics, Atlanta; Software; $18 million (3rd)

Investors: Bain Capital Ventures (lead), Cordova Intellimedia Ventures, Encubate Technology Ventures, Robinson-Humphrey Netlanta Fund, SSM Ventures, Symphony Technology Group and UPS Strategic Enterprise Fund

6. Greenway Medical Technologies, Carrollton, Ga.; Software; $15 million (3rd)

Investors: Individuals

7. Norak Biosciences, Research Triangle Park; Biotech; $13 million (2nd)

Investors: Noro-Moseley Partners (lead), Alexandria Real Estate Equities, Aurora Funds, Intersouth Partners, Koch Ventures and Mitsui & Co. Venture Partners

8. N2 Broadband, Duluth, Ga.; IT services; $10 million (2nd)

Investors: Highland Capital Partners (lead) and AOL Time Warner Ventures

9. Peak 10, Charlotte; IT services; $9.2 million (3rd)

Investors: Frontier Capital and Seaport Capital

10. MediaSpan, Durham; Media; $8.5 million (1st)

Investors: Covestco-Seteura, Rustic Canyon Group, Southeast Interactive Technology Funds

11. Fast-Talk Communications, Atlanta; IT services; $8.5 million (2nd)

Investors: Boston Millennia Partners (lead), Atlanta Technology Angels, Cordova Ventures, HIG Ventures and SAIC Venture Capital

12. GenPhar, Mount Pleasant, S.C.; Biotech; $8 million (1st)

Investors: Individuals

13. NetOctave, Morrisville, N.C.; IT services; $7.8 million (2nd)

Investors: Intersouth Partners (lead), Intel Communications Fund, Kitty Hawk Capital, MCNC, North Carolina Enterprise Fund and Wakefield Group

14. iOnosphere, Greenville, S.C.; Telecom; $7 million (2nd)

Investors: Pharos Capital (lead) and Trelys Venture Partners

15. Netifice Communications, Atlanta; Telecom; $6.5 million (3rd)

Investors: Boston Millennia Partners, Columbia Capital and HIG Ventures

16. HAHT Commerce, Raleigh; Software; $6 million (2nd)

Investors: Canaan Partners

17. ChannelAdvisor, Morrisville, N.C.; Software; $5.7 million (2nd)

Investors: Genesis Venture Partners (lead), eBay, Southern Capitol Ventures, The Atlantis Group and Tri-State Investment Group

18. Lancope, Alpharetta, Ga.; Software; $5.55 million (1st)

Investors: GMG Capital Partners and H.I.G. Capital

19. EG Technology, Atlanta; Telecom; $5.5 million (1st)

Investors: Noro-Moseley Partners (lead), Gray Ventures, HIG Ventures and Yamacraw Seed Capital

20. KnowledgeStorm, Alpharetta, Ga.; IT services; $5.25 million (2nd)

Investors: Sterling Venture Partners (lead), Apex Venture Partners, Imlay Investments, Live Oak Equity Partners and Total Technology Ventures

21. Datatrac, Atlanta; Software; $5 million (NA)

Investors: Megunticook Fund

21., Atlanta; Internet; $5 million (4th)

Investors: Healthsouth, UBS Warburg

21. SiteScape, Wilmington, N.C.; IT services; $5 million (2nd)

Investors: Echelon Ventures, SAIC Venture Capital

21. CipherOptics, Raleigh; IT services; $5 million (1st)

Investors: Kodiak Venture Partners

21. eCompanyStore, Atlanta; Internet; $5 million (NA)

Investors: ITC Holdings

26. AppGate, Durham; IT services; $4 million (3rd)

Investors: ABN Amro (co-lead), GE Equity (co-lead), Bure Equity, Industrifinans, Innovationskapital and Pythagoras

27., Atlanta; Internet; $4 million (NA)

Investors: Individuals

28. DarPharma, Chapel Hill; Biotech; $3.2 million (1st)

Investors: Stanley Foundation and individuals

29. Trinity Convergence, Raleigh; Telecom; $3.1 million (1st)

Investors: Core Capital Partners, Intersouth Partners, Mid-Atlantic Venture Funds

30. ConstructWare, Alpharetta, Ga.; Software; $3 million (3rd)

Investors: Cordova Ventures, Live Oak Equity Partners and Smith Harbor Ventures

31. LiveWire Logic, Morrisville, N.C.; IT services; $2.8 million (2nd)

Investors: Gray Ventures (lead), A.M. Pappas & Associates, The Atlantis Group, Charlotte Angel Partners, Research Triangle Ventures, Tri-State Investment Group, truePilot and individuals

32. nTouch Research, Raleigh; Pharmaceutical services; $2.6 million (3rd)

Investors: Canaan Partners (co-lead), Intersouth Partners (co-lead), Bioventures and Tri-State Investment Group

33., Atlanta; Internet; $2.5 million (1st)

Investors: Imlay Investments and individuals

34. Relativity Technologies, Cary; Software $2 million (3rd)

Investors: Noro-Moseley Partners and Wakefield Group

35. Somatocor, Atlanta; Biotech; $1.7 million (seed)

Investors: Alliance Technology Ventures

36. epipeline, Atlanta; Internet; $1.5 million (3rd)

Investors: Crossbow Ventures

37. Gentris, Morrisville, N.C.; Biotech; $1.5 million (1st)

Investors: Exelixis, Research Triangle Ventures and individuals

38. Fortel DTV, Duluth, Ga.; IT services; $1 million (NA)

Investors: Individuals

39. BuildLinks, Raleigh; Software; NA (2nd)

Investors: Knier and Associates

39. Waveguide Solutions, Charlotte; Hardware; NA (2nd)

Investors: Academy Venture Funds, Southeast Interactive Technology Funds

39. ZapMedia, Atlanta; Telecom; NA (2nd)

Investors: Five Paces Ventures

39. MindValve, Charlotte; Software NA (Seed)

Investors: Academy Venture Funds